CASP-004A
Ac-WEHD-CHO
Ac-Trp-Glu-His-Asp-CHO
Size:1.0
P1(RMB):153
MW:611.61
One letter sequence:Ac-WEHD-CHO
Molecular Formula:C28H33N7O9
Description:Very potent reversible inhibitor of caspase-1 (ICE) that contains the optimal tetrapeptide recognition motif for this enzyme. With a Ki of 56 pM, it displays the most potent reversible, peptide-based inhibitors described for any protease. For caspase-8 a Ki of 21.1 nM has been reported.
Literature Reference:T.A. Rano et al., Chem. Biol., 4, 149 (1997); M. Garcia-Calvo et al., J. Bio. Chem., 273, 32608 (1998)
Cas:[189275-71-6]