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AMYD-047A
(Asn670,Leu671)-Amyloid b/A4 Protein Precursor770 (667-675)
Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe
Size:1.0
P1(RMB):398
MW:1023.1
One letter sequence:SEVNLDAEF
Molecular Formula:C44H66N10O18
Description:Peptide substrate that corresponds to the mutant junctional sequence of the amyloid precursor protein (APP) found in a Swedish family with early-onset Alzheimer's disease, henceforth referred to as the \"Swedish \"mutation. The peptide has been used for assaying cleavage at leucine-aspartate by cathespin G and chymotrypsin, whereas neither cathepsin B, D, nor L generated any products.
Literature Reference:M. Citron et al., Nature, 360, 672 (1992); M. Mullan et al., Nature Gen., 1, 345 (1992); S.R. Sahasrabudhe et al., J. Biol. Chem., 268, 16699 (1993)
Cas: